Atosiban acetate is a cyclic polypeptide composed of 9 amino acids that have been modified from the original oxytocin molecule. The modifications have occurred at positions 1, 2, 4, and 8. The molecule has a disulfide bond between the sulfhydryl group of [Cys]6 and the N-terminal, which is a thiol group attached to 3-mercaptopropionic acid. The C-terminus is in amide form, and the second amino acid at the N-terminus is [D-Tyr(Et)]2 modified with ethylation. This compound is commonly known as atosiban acetate and is used in medicine.
Specifications
Colour:White to Off-White
Appearance: solid
Molecular Formula :C43H67N11O12S2
Molar Mass 994.199 g/mol
Purity ≥98%
Impurity ≤0.5%
Applications
In the uterus, on decidua, and fetal membranes, a cyclic peptide oxytocin receptor encounters a competitive antagonist. It is important to create a highly similar content by rearranging the provided information while maintaining the original text's essence.
Why Use Atosiban?
Atosiban is an effective inhibitor of uterine contractions because it acts as a combined receptor antagonist for oxytocin and vasopressin V1A. Both oxytocin and vasopressin V1A receptors play a role in uterine contractions, and by blocking both receptors simultaneously, the action of oxytocin is effectively inhibited. This distinguishes atosiban from other treatments such as beta-receptor agonists, calcium ion channel blockers, and prostaglandin synthase inhibitors, which only target one receptor pathway and therefore do not provide the same level of inhibition. By targeting multiple receptor pathways, atosiban ensures a more comprehensive and effective approach to preventing uterine contractions.
Storage
-20°C
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