Derived from bee venom, melittin is a peptide known for its immune-related properties. It has been found to stimulate PLA2 and increase the activity of high-molecular-weight enzymes. Moreover, melittin has been shown to exhibit natural antibacterial, antiviral, and anti-inflammatory characteristics. Recent studies suggest that melittin also has multiple anticancer effects, inhibiting cell proliferation and inducing apoptosis in various cancer cell lines, including lung, cervical, liver, ovarian, prostate, breast, and gastric. Being an amphipathic hemolytic peptide, melittin exerts its potential anticancer effects by directly necrosing cells. Melittin also inhibits EGF-induced cell invasion by blocking the PI3K/Akt/mTOR signaling pathway - a mechanism that's more specific to breast cancer cells.
Specifications
CAS NO.: 20449-79-0
Formula: C131H229N39O31
Molecular Weight: 2846.463
Appearance: no data available
Purity (area%, HPLC ) ≥ 98.0%
Solubility: H2The concentration of the product is 25 mg/mL or 8.78 mM, with a solubility slightly soluble or insoluble at 1 mg/mL. To reiterate, the product's concentration is 25 mg/mL or 8.78 mM, and its solubility is only slightly soluble or insoluble at 1 mg/mL.
Application
Melittin has a wide range of applications in the field of medicine, particularly for alleviating pain, treating inflammatory diseases, and combating cancer.
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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